クリノスタットによる微小重力環境が人工骨格筋収縮力に与える影響

抄録

In recent years, it has been recognized that the loss of muscle mass as a result of ageing is the cause of various diseases such as bedriddenness. Normally, the muscle proteins that constitute muscles are continuously being built and broken down to maintain a constant amount of muscle strength, but due to ageing and lack of exercise, the amount of muscle protein breakdown exceeds the amount of synthesis. This reduces muscle mass and the body's motor function, resulting in bedriddenness. This condition is called "sarcopenia" and the number of patients is increasing. There is currently no specific treatment for this symptom, and research is underway to find an effective treatment. Traditionally, studies have used drug-treated or genetically engineered mice to model muscle disease. However, due to the many extraneous factors in animal experiments and the inferior quantification due to individual differences, there is a need for cell assay tools that can be evaluated more quantitatively and rapidly. In this study, we aim to establish a more reproducible muscle disease model by producing artificial muscle using a C2C12 cell line and performing culture experiments in a microgravity environment using a clinostat.