脂質二分子膜－表面探索からセンサ応用に向けて－

抄録

Lipid bilayer membranes are critical cellular components that compartmentalize cells and organelles and provide the platform for various physiological functions such as molecular recognition, signal transduction and energy conversion. Dysfunction of the plasma membrane is directly linked to cell death, and, in this context, the measurement of membrane function is extremely important for physiological and pathological insights. On the other hand, lipid bilayers can be artificially reconstituted on solid substrates. Such artificial lipid bilayers are not only useful as biomembrane models but are also expected to be used as interfaces for nano-bioelectronic sensors. In this talk, I would like to present our recent research on the study of lipid membrane functions from two aspects: 1) the development of an electrochemiluminescence (ECL) imaging system to elucidate the effects of peptides on lipid membranes, and 2) the use of artificial lipid membranes for the detection of lipid vesicles with the solid-state nanopore sensor.