Design algorithm for self-expanding vascular stents with suitable properties based on multidimensional data mapping

Abstract

Drug-eluting stents (DES) have dramatically improved the early restenosis of conventional bare metal stents. However, several challenges remain in the long-term prognosis of DES, such as thrombosis, late restenosis, and hemorrhagic complications. In order to fundamentally improve the outcomes, it is essential to prevent restenosis and promote endothelialization by optimizing contact force in the early phase after implantation. In this study, a data map consisting of multidimensional data on stent shape variables, radial force, and physical properties of the vessel was constructed, and a design method for stents with the desired performance was developed by introducing boundary conditions corresponding to stent implantation.