Anisotropic fatigue strength of the cross-ply fiber-metal laminate GLARE 3 under constant-amplitude loading conditions has been studied. Tension-tension fatigue tests were performed at room temperature on five kinds of plain coupon speciments [0/90]_θ with different off-axis fatigue strength rapidly decreased for every off-axis angle in the intermediate range of the fatigue lifetime, and it was followed by a fatigue limit. A more excellent fatigue performance of GLARE 3 in comparison with the high strength aluminum alloy was observed only in the glass fiber directions (0°and 90°) for the low fatigue lifetime range. The off-axis fatigue data plotted using the strength ratio were approximately represented by a single master S-N curve.