抄録
Hemodynamics stresses are known to be able to degenerate the arterial wall and be involved in the pathogenesis of aneurysm formation and development. The present study numerically simulates the formation and growth of an aneurysm arising from a curved artery focusing on the interplay between the wall shear stress, arterial wall degeneration and deformation. It was hypothesized that if the local wall shear stress is higher than a threshold value, the Young's modulus of the wall is decreasedat'a fixed rate. The computer simulations clearly show the relationship among the change in the shape of the blood vessel, distribution of wall shear stress, and the degeneration of vessel wall during the progression of aneurysm, providing us new insight into the mechanism of aneurysm formation and development.
