An anisotropic material model is applied to three dimensional simulation on inhomogeneous deformation in polycrystalline aggregate. The variation of stress-strain response appears due to the anisotropy and macroscopic homogeneity is achieved in polycrystalline model in the way that the macroscopic stress-strain responses seem to be homogeneous. However each crystal reveals complicated responses due by the neighborhood. It is found that the microscopic inhomogeneity is governed by the misfit of anisotropy between the neighboring grains.