The purpose of this study is to generate and characterize a titanium alloy microneedle, which can be equipped in Bio-MEM such as HMS (Health Monitoring System) for the blood sugar level measurement. One of the most important subject for the Bio-MEM is a microneedle with a inner diameter of 100μm and a outer one of 200μm, which mimics female mosquito's painless blood extraction mechanism. In this study, a microneedle generation was performed through 1) selection of a biocompahble material from titanium alloys by the cytotoxic assay, 2) RF magnetron sputter generating of the microtubes with a inner diameter of 100μm, a outer one of 200μm and a length of 4mm, and 3) evaluation of suction by the vacuum blood extraction tests. Consequently, the titanium microneedle obtained the flow rate of 6.2μl/sec.
