747 Effect of Cells on the Change in the Mechanical Properties of Bone Tissue during Cyclic Compression Culture
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We found that the stiffness of bone tissues cultured under cyclic compression increased significantly. But it was not clear whether this change was an active adaptation of the cells in bone or it was just a passive change of the tissue. To clarify this, bone tissues including those treated with liquid nitrogen to kill cells were cultured under cyclic compression. Cell viability was measured in specimens cultured in various conditions. The stiffness of bone tissues without living cells did not increase. Thus, we confirmed that the stiffening of the specimens exposed to cyclic compression culture is an active change in the bone tissue.
