We simulated the healing behavior of bone after plate fixation of a diaphyseal fracture using the growth-strain method. The growth criterion parameters on the strain energy density of cortical bone were investigated by applying the finite element method to a three-dimensional model of a normal cortical bone. Next, the fracture healing model fixed using a plate with 4 or 6 screws was analyzed in the case where the clamping force of one screw was 250N. The growth analysis of the diaphyseal fracture was performed using the previously obtained growth criterion parameters. The optimal operation method was in the case where 4 screws were clamped at the nearest bone fracture.