Seismic response of structures is nonstationary random process. Mean square value is one of the representative statistical values. Calculating method for such a response is complicated. In this paper, a simplified calculation method for integral of mean square value of the response of the secondary system is proposed using mean square value of stationary random process. Nonstationary characteristics of amplitude and frequency are considered. It is found that the proposed method gives exact values of integral of mean square value of the response.