S0201-3-5 コラーゲン系scaffoldによる再生骨の力学特性(骨再生と骨再建のためのバイオマテリアル(3),社会変革を技術で廻す機械工学)

抄録

In this study, effects of cell seeding and mechanical stimulus on the multiplication behavior and compressive mechanical property of collagen-based scaffolds were examined. Osteoblast-like cells, MC3T3-E1, were seeded in two different types of collagen scaffold, namely, PET fiber/collagen and honeycomb structured collagen up to 30 days and compression tests were performed after 14 and 30 days. The honeycomb collagen exhibited higher modulus than the PET/collagen and the modulus tends to increase due to cell seeding. Compressive mechanical stimulus was also added to the seeding systems of the honeycomb collagen with cells and such stimulus effectively increased the cell number and resulted in dramatic increase of compressive modulus.