Present product includes very small designed structure. The very small designed structure directly influences the property and the shape of product. It is important for product designer or material designer to get overview and forecast of the property of designing product or material. In order to make multi-scale product design and multi-scale engineering simulation of designing product or material, a framework of multi-scale product design and simulation system is proposed. Multi-scale product design and simulation system consists of multi-scale spatial model and multi-scale simulation modules. Multi-scale spatial model is an interface for multi-scale simulation modules, and a bridge between micro scale level simulation and macro scale level (human scale level) simulation.