The infrared thermography is a useful tool for the inspection of subsurface defects and damages, such as voids or delaminations, in concrete structures. As one of the NDT techniques by infrared thermography, passive thermographic NDT has been applied to the remote inspection of building wall and concrete structures. However, it is difficult to detect defects, when temperature difference between defect area and sound area is smaller than temperature resolution of thermal sensor. In this research, the self reference lock-in thermographic method is applied as the effective technique for signal to noise ratio improvement. Natural weather change from shine to cloud and sunset affects to temperature change on the objective surface. The wave forms of these temperature changes are measured by infrared thermography and processed by the lock-in analysis scheme. It is found from the experimental studies that the resolution of defect inspection was improved by the present the self-reference lock-in technique.