We examine effective cooperation of simulation technique and experimental technique in this report. A molecular-dynamics technique for determining the adhesion strength of the interfaces between different materials has been developed. This technique evaluates the adhesion strength by calculating the adhesive fracture energy defined as the difference between the total potential energy of the material-connected state and that of the material-separated state. the adhesion strength determined by this technique agrees well with that measured by scratch testing And,crack propagation prediction by a macro scale model is introduced.. In this model, the fatigue life of solder is evaluated based on the damage that accumulates during crack propagation, and the crack paths are automatically calculated. Calculation mesh size is adjusted by this method so that a calculation result may agree with an experimental result.