メッシュ構造足場材料における力学的負荷が細胞増殖に与える影響

抄録

The scaffold has been used to form a three-dimensional tissue in tissue engineering. It has been known that not only the mechanical properties of scaffold, but also the mechanical stress affect the cell function and tissue structure. However, it is difficult to observe the effect of mechanical stress on each cell in the case of the three-dimensional scaffold. In this study, the effect of tensile strain on the cell adhesion and cell proliferation ratio by using the planar nylon mesh scaffold was investigated. It was found that the cell proliferation ratio increased in case of large strain. It was suggested that the high stress effectively worked to cell proliferation.