Abstract
Chemo-mechanical energy conversion of an organic engine in the autonomous drug release system was improved by modifying its physical structure. The organic engine was fabricated by separating a cylindrical cell into a top-cell (gas-phase) and a bottom-cell (liquid-phase) by glucose oxidase enzyme immobilized membrane and, it generates decompression autonomously by catalysis of glucose oxidation. Therefore, in order to increase decompression rate, methods to enlarge area of the enzyme membrane per volume of the gas chamber were proposed and evaluated. As a result, two times higher output that can make the system possible to actuate on low glucose concentration close to blood sugar was obtained.
