Abstract
There has been increasing interest in developing a single-molecule technique for biosensing applications such as viral screening and DNA sequencing. Solid-state nanopore, a nanometer-sized hole sculpted in a thin membrane on a silicon wafer, is one of the promising platforms that enables electrical detections of single-molecules by measuring resistive ionic current pulses during their translocation through a pore. In this presentation, I will briefly introduce recent progress in nanopore technologies. Then, I will present an ongoing effort devoted for realizing sequencing by transverse tunneling current through a single-molecule DNA by using a pair of nanoelectrodes embedded in a pore and discuss the potential of the method for the goal of nanopore sequencers.
