The Proceedings of the Symposium on Micro-Nano Science and Technology
Online ISSN : 2432-9495
2013.5
Session ID : 5PM1-C-2
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5PM1-C-2 On-chip in vitro model replicating metabolism pathway
Naofumi HorioHiroshi Kimura
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Abstract
In this research, we propose an on-chip in vitro model based on a microfluidic device for pharmacokinetic studies. To construct an in vitro pharmacokinetic model that appropriately models in vivo conditions, physiological parameters such as the structure of internal circulation and volume ratios of each of the organs were mimicked using microfluidic networks. Pharmacokinetic study using tegafur was conducted to model the effects of biologically activate anticancer drugs. The efficacy of the anticancer drug in the target cells was successfully demonstrated using the device. This device can thus be used as an in vitro organ model to predict the pharmacokinetics of drugs in the human body.
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© 2013 The Japan Society of Mechanical Engineers
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