A precise 3D CAD model of mosquito central labrum and side maxillae, i.e., totally three needles, was constructed. Mosquito inserts these needles inside the human skin with vibration. To confirm the effect of vibration, explicit FEM analysis was conducted using the model. LS-DYNA was adopted as the software. In this report, only the central needle was preliminarily considered among the three, and this needle was inserted into the skin in the simulation. It is proven that the resistance force was reduced by 5 % at the maximum with applying vibration. It is also proven that the higher frequency makes the resistance lower. The simulation results indicate the effect of vibration on easy needle insertion without buckling.