マイクロゲルビーズ担体を用いたナノ粒子の超音波徐放

抄録

This paper describes an ultrasonic response on demand drug delivery system (DDS) of microgel beads carrier with particles encapsulated to enhance drug release. The goal of this research is an establishment of the highly effective drug release employing ultrasonic. In the first step, we demonstrated the release of fluorescence particles form microgel beads using ultrasonic. Incidentally, the beads were produced using calcium alginate as the main agent by a centrifugal separator. The sustained release was evaluated by measuring the fluorescence intensity of the fluorescent particles released from the beads by irradiating ultrasonic waves. Almost all particles were released by irradiating 50% ultrasound for 20 min. The method may provide benefit to a safe and accurately control for improving DDS.