Due to ongoing progress in material surface treatments and in micro/nano scale processing, it is feasible to fabricate various structures at micro/nanometer scale on a solid surface. The molecular dynamics simulations have been applied to understand static structures and transport phenomena at the molecular scale at a liquid-solid interface, and a substantial thermal resistance was found at the liquid-solid interface. In the present study, the effects of nanoparticles adherent to a surface on the thermal resistance at a liquid molecule-solid interface were investigated directly by the nonequilibrium classical molecular dynamics simulations. The reduction of the interfacial thermal resistance caused by the nanoparticle adhesion can be observed only when the high wettability nanoparticles are adherent to the low wettability surface.