Host: The Japan Society of Mechanical Engineers
Name : [in Japanese]
Date : May 10, 2017 - May 13, 2017
We propose a new method for quantifying red blood cell (RBC) deformability based on the combination of a microfluidic constriction channel and a “robotic pump”, which enable real-time high speed, precise manipulation of a RBC inside the channel. By the manipulation of a RBC around the narrow path, we applied deformation for a specified time. After the launch from the narrow path, the cell shape recovers depending on the loading time and amount of adenosine triphosphate (ATP). The analysis of the recovery shows that these dependences appears in the timescale of 100 s, which could be involved in that of shape adaptation to the applied deformation stress. Finally, the quantitative comparison between the recovery time after the continuous and repetitive loadings is discussed.
