Development of micro structure for force measurement with intracellular FRET

Abstract

In this paper, we proposed a micro size wireless force sensor which was used fluorescence resonance energy transfer (FRET) function expressed cells. In order to develop the force sensor, a microstructure which could transfer external force to expressed cells was designed. The micro structure which was made of Poly(dimethylsiloxane) was assembled by the photolithography method. A mold of the micro structure was made by the dry etching. The scale and mechanical property of the assembled micro structure was evaluated by a laser microscope and a force transducer. Then, it was confirmed that the scale and the mechanical property of the assembled micro structure were closed to that of computer simulation model.