浸透流による流体力学的せん断応力が動脈壁内部の物質輸送機構に及ぼす影響(オーガナイズドセッション13 バイオシステムにおける熱・物質移動)

抄録

The internal elastic lamina (IEL) which separates the arterial intima from the media affects macromolecular transport across the medial layer. In the present study we have developed a two-dimensional numerical simulation model to resolve the influence of the IEL on convective-diffusive transport of macromolecules in the media. The model considers interstitial flow in the medial layer that has a complex entrance condition due to the presence of leaky fenestral pores in the IEL. Results for Low density lipoprotein (LDL) demonstrate a range of interesting features of molecular transport and uptake in the media that are determined by considering the balance among convection, diffusion and smooth muscle cell (SMC) surface reaction.