抄録
The isolated guinea-pig ileum was heated at various temperatures (46-48°C) for various times (5-30 min) and the responses of the ileum to acetylcholine, histamine, potassium chloride and transmural stimulation were investigated.
The responses to acltylcholine, histamine and KCl were depressed by heating at the same degree while it was impossible to depress selectively those to acetylcholine and histamine. The responses which were decreased after heating under mild condition sometimes showed reversible recovery. These facts show that the resistance of both acetylcholine and histamine receptors to thermal alteration is similar to that of the muscle membrane.
Meanwhile, the contractions obtained with nicotine and transmural stimulation disappeared selectively under such the conditions of heating that the responses to acetylcholine, histamine and KCl were kept almost normal, namely, it means that nervous elements were damaged selectively by heating.
