An influence of a new antispasmodica, SA-504, 1, 1-Dimethy1-5-methoxy-3-(dithiene-2-ylmethylene)-piperidinium bromide upon the myogram and intraluminal pressure of the human colon was studied. The myogram and intraluminal pressure curves were measured by inserting a balloon attached with electrodes into the area approximately 25-30 cm proximally from the anus in three patients with irritable colon syndrome. The increased intestinal motility of the sigmoid colon, which had been previously stimulated by either subcutaneous injection of 1.0 mg of neostigmin or intravenous administration of 1 u/kg of secretin, was inhibited about 3-5 minutes after intramuscular injection of 7.5 mg of SA-504.
It may be concluded that SA-504 has an inhibitory effect upon the human large intestinal motility and the drug may be usefll clinically.
