ディンプル形状表面付与PETファイバーの創製

抄録

Replacement of an aneurysm with a vascular graft and treatment using a stent graft － a covered stent: combining a covering material with a metal stent － is conducted for aneurysm. A vascular graft is used as covering material of the current stent graft. A large-diameter stent graft has good stent patency. In the case of the stent graft that has less than 6 mm of caliber, covering material that promotes endothelialization is necessary in order to prevent thrombus formation. For the covering material, nanofibers, which have been applied to regenerative medicine due to the similarity to extracellular matrix of a native vessel, is expected to be used. In previous studies, when the fiber diameter of the scaffold was more than 1 μm, cells were reported to infiltrate more into the scaffold, and the porous scaffold was clarified to offer better surfaces to anchor and culture endothelial cells as compared to a nonporous scaffold. Thus, fibers with nano-order dimples are expected to promote endothelialization, and the fabrication process of these fibers has to be developed. In this study, in order to develop the fabrication process of PET fiber with dimples, PET fibers were fabricated under various processing parameters. Dimples were successfully formed on PET fiber surface under high humidity condition by using Hexafuoro-2-propanol(HFIP) which can dissolve PET and has rapid volatilization speed, and Ethylene glycol(EG) which cannot dissolve PET and has slow volatilization speed for solvent in electrospinning.