Abstract
We examined the frequency of several short forms of spliced Murine double minute 2 (MDM2) transcripts and their correlation with clinicopathological features in human breast cancer. There was no significant correlation between the expression of splice variants and tumor size or hormone receptor status. However cases with spliced MDM2 transcripts tended to be of a more aggressive type with axillary lymph node involvement and extensive necrosis in the tumors. We anticipate that the variants will be confirmed as a novel prognostic marker.
