Abstract
Schwannoma is a benign tumor derived from Schwann cells and can develop throughout the body; however, its occurrence on the lips is relatively rare. Herein, we report a case of schwannoma on the lower lip.
A 28-year-old woman presented with a painless swelling on the right side of her lower lip, which had been present for ＞10 years. The patient visited our department in October 2022 for further examination and treatment. Magnetic resonance imaging revealed a well-defined, elastic mass measuring 20×10-mm with healthy mucosal coloration. The mass exhibited low signal intensity on T1-weighted images and high signal intensity on T2-weighted images. Based on these findings, a clinical diagnosis of a lower lip tumor, was made, and surgical excision was performed under general anesthesia in January 2023. Histopathological examination revealed that the mass was encapsulated by a fibrous capsule with a mixture of areas containing spindle-shaped nuclei and Verocay bodies, as well as regions with a sparse reticular arrangement of cells and vacuolar degeneration in the stromal tissue. The mass was positive for S100 protein on immunohistological examination, leading to a diagnosis of Antoni AB mixed schwannoma. Nine months after surgery, the patient is doing well without recurrence.
