Abstract
This study examined the production of phlebitis by anticancer drugs in a rabbit model, and observed the histopathology of phlebitis in greater detail, including the histological effects of poultice application on phlebitis. Macroscopically, after 24 h of grouting, in every 6 rabbits has extended auricular veins and perivascular, and after 72 h grouting, and after 72 h grouting, strong auricle redness was present, but no differences were found between all groups. Histologically, after 24 h, loss of venous endothelial cells and presence of perivascular edema and thrombus were identified. After 72 h, these findings were more severe. Comparing pathology after 72 h, rabbits that underwent grouting alone showed the most severe findings, followed by rabbits that received a hot poultice after grouting, and rabbits that received a cold poultice after grouting as the mildest. These findings suggest that application of a cold poultice is the most effective method and hot poultice is contraindicated when phlebitis is caused by anticancer drugs.