EXPERIMENTAL STUDY INTO THE EFFECTS OF APPLYING GAUZE MEDICATED WITH ACRINOL SOLUTION TO SKIN INJURIES RESULTING FROM EXTRAVASATION OF MEDICAL DRUGS

Abstract

Clinically, application of gauze medicated with acrinol solution is considered to be one of the major treatments of extravasation and is useful for reducing the severity of skin injury. However, there is little scientific basis for the effects of an acrinol compress on skin injuries. Therefore, this study focused on the effects of applying an acrinol compress to skin injuries resulting from extravasation of medical drugs. Skin injuries were induced on the backs ofrats that had been administered two types of medication (Adriacin^® and Cercine^®) subcutaneously. After extravasation of each drug, an acrinol compress was applied to the affected part of the skin for 4 days. Both gross and microscopic examinations were performed. Biopsy samples were then taken and subjected to microscopic examination. Microscopic observation revealed severe edema and inflammatory cell proliferation in the subcutaneous layer of the rat skin at the affected sites. The present study revealed no microscopic changes in the skin injuries after applying the acrinol gauze. Therefore, these findings do not demonstrate the effectiveness of applying gauze medicated with acrinol solution in the treatment of skin injuries resulting from extravasation of medical drugs.