2021 Volume 26 Issue 1 Pages 99-103
von Willebrand disease (VWD) is a rare hematologic disease comprised of six subtypes. It occasionally presents hemorrhagic diathesis. A 46‒year‒old Japanese man diagnosed with type 2A VWD was emergently transported to the hospital. At presentation, he exhibited sustained amnesia but no other neurological deficits, scoring 14 points on the Glasgow Coma Scale. Cranial computed tomography scans revealed a thin acute subdural hematoma, cerebral contusion, and traumatic subarachnoid hemorrhage. The patient underwent conservative treatment with intranasally administered 1‒desamno‒8‒D‒arginine vasopressin (DDAVP) and an intravenous infusion of tranexamic acid. During his hospitalization, no electrolyte imbalance or other adverse events were noted. DDAVP may be effective for the treatment of patients with traumatic intracranial hemorrhages complicated by VWD.
