Abstract
Two kinds of choline deficient diet, one is low in protein and the other is high inprotein and fat and low in methionine, were fed to rats and the results were as follows.
1) Diet low in protein produced fatty liver when casein, used as a source of protein, waspurified with water and alcohol completely, but did not occur the kidney damage.
In one case, acute liver necrosis was found after high peroxide value of liver lipid hadrapidly dropped.
2) Diet high in protein and fat and low in methionine, produced characteristic hemorrhagickidney in choline deficiency even though fatty liver was not so remarkable.
This difference might be due to the quality and quantity of protein or fat used inthese experiments.
3) Cystine and tocopherol enhanced choline deficiency while choline, vitamin B12, and methionine had the protective effect.
