Abstract
Fourty albino rats (70-90g of body weight) were divided into four groups, and fed low fat (1% corn oil) and high carbohydrate (74% of starch, glucose, fructose and sucrose, respectively) diet for ninety days.
The content of triglyceride, cholesterol and phospholipid were observed in liver and serum, and the activity of hepatic fructokinase were also estimated.
In the fructose and sucrose group the body weight gains were lower, and the ratio of liver, heart, kidneys and spleen per body weight were higher than other two groups. In liver, contents of triglyceride and total cholesterol were high in the starch and the glucose group, free cholesterol in the sucrose group and phospholipid in the fructose group. In serum, contents of triglyceride and total cholesterol were high in the sucrose group. There was no significant difference in the hepatic fructokinase activity. However, somewhat higher activity was observed in the fructose group than the others.
The low content of hepatic triglyceride and total cholesterol observed in the fructose and sucrose group was considered to be caused by the quantity and quality of dietary fat. It was also considered that metabolism of fructose and triglyceride was influenced by the age of experimental animals.
