Abstract
From the standpoint of insulin therapy for diabetes mellitus, an understanding was sought as to how metabolic activities changed in response to a daily administration of insulin.
In this paper adaptive responses such as changes of body weight, food intake, blood glucose and insulin concentration were observed in alloxan diabetic rats administered insulin (1I. U. /100g of body weight/day) for long period.
1) Daily administration of insulin to alloxan diabetic rats brought a more significant gain in body weight (4.4g/day) during a 5 week period than that of a saline solution only (2.4g/day).
2) The administration or non-administration of insulin to alloxan diabetic rats showed no significant -difference in their food intake.
3) The effect of insulin on a high glucose level in the blood maintained only for 90 minutes after injection.
4) Endogenous immunoreactive insulin in the blood showed rather a low level in alloxan diabetic rats with insulin than those without insulin.
