Abstract
The effect of lysine and vitamin D3 on the rat intestinal Ca absorption was observed. Rats were raised on vitamin D deficient diet which protein was replaced with amino acid mixtures. Lysine content of the diet was either 1.35% or 0.45%. These two lysine groups were further divided into vitamin D deficient and vitamin D3 dosed group.
1.35% lysine-vitamin D3 dosed group showed the best growth, followed by 1.35% lysine-vitamin D deficient group. The growth of 0.45% lysine group was extremely retarded and was not influenced by vitamin D status.
Intestinal 45Ca transport in the everted sac obtained from vitamin D deficient group was not influenced by lysine content in the diet, but the response of 45Ca transport by vitamin D3 was greater in 1.35% lysine group than in 0.45% lysine group. The same tendency was observed in CaBP content in the duodenal mucosa.
These results suggest that the stimulatory effect of lysine on the intestinal calcium transport would be visualized by vitamin D.
