Abstract
Total lipid and lipoperoxide level in the liver was elevated significantly when the rats were fed for 10 weeks on high fat diet containing 40% corn oil. After the feeding, serum glutamic pyruvic transaminase (S-GPT) was also significantly elevated, suggesting some damage in the liver.
To know some of the nature of this liver damage, carnitines (D- and L-) and pantetheine were supplemented to this high fat diet. Although carnitine supplementation depressed significantly the rise in lipoperoxide level during the experimental period, it did not depress the rise in total lipid for more than 7 weeks. Pantetheine supplementation also reduced the rise in lipoperoxide after 10 weeks of the feeding, but could not reduced the rise in total lipid level at all. No S-GPT elevation was seen at the end of 10 weeks supplementation experiments.
It was concluded that elevation in lipoperoxide level in the liver had more intimate relation than the rise in total lipid to the liver damage indicated by the elevation of S-GPT induced by high fat diet feeding.
