2016 年 33 巻 3 号 p. 357-361
Making the center of the refractory migraine is chronic migraine (CM) and medication overuse headache.
CM is a disabling neurological condition affecting 0.5–2% of the population.
In the current third edition of the International Classification of Headache Disorders, medication overuse is no longer an exclusion criterion and CM is diagnosed in patients suffering from at least 15 headache days per month of which at least eight are related to migraine.
CM is difficult to treat, and preventive treatment options are limited.