神経治療学
Online ISSN : 2189-7824
Print ISSN : 0916-8443
ISSN-L : 2189-7824
シンポジウム1:神経領域における創薬研究の新たな展開:神経機能の回復をめざして
iPS細胞を用いた脊髄損傷に対する再生医療
名越 慈人岡野 栄之中村 雅也
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ジャーナル フリー

2020 年 37 巻 3 号 p. 310-312

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Spinal cord injury (SCI) is caused by high energy trauma such as traffic accidents, falls, and contact sports. Breakage of spinal stability results in permanent neurologic dysfunction. Spinal fixation surgery and subsequent rehabilitation are the only procedures for the treatment of SCI, but they cannot cure the irreversible changes of the spinal cord. To overcome this situation, we have conducted basic research to establish cell transplantation therapy using human iPS cell–derived neural precursor cells (NPCs). We reported efficacy of NPCs after transplantation. At the same time, however, some iPSC–NPCs showed tumor–life proliferation in the spinal cord, and provision for this unfavorable phenomenon is urgently necessary. We have developed several methods to inhibit tumor formation, and will introduce them in this review. So far, we have worked towards the clinical application of human iPSC–NPCs for SCI. This exciting clinical research will start soon around the corner.

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© 2020 日本神経治療学会
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