Review/Advances in Neurological Therapeutics (2019). Motor neuron disease

Abstract

Motor neuron diseases (MND), including amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), and spinal bulbar muscular atrophy (SBMA) are devastating neurodegenerative diseases that primary affect motor neurons. Nucleic acid–based therapeutics and gene transduction therapies are novel treatment methods for MND, which have the potential to transform these incurable diseases into treatable diseases. This review provides an overview of preclinical and clinical advances in MND research, future issues and prospects, and also summarizes selected key literature on therapeutic approaches in 2019.