Review/Advances in Neurological Therapeutics (2019). Brain tumor and granulomatous disease

Abstract

The treatment of brain tumors and granulomatous disease in the brain represents a serious unmet medical need in the field of neuro–oncology. Eventhough many effective compounds have demonstrated success in treatingperipheral tumors with targeted agents, one aspect of this lack of success inthe brain may be related to poor delivery of otherwise effective compounds. Thisreview discusses some issues that are pertinent to precision medicine for glioma, brain metastases and neurosarcoidosis with some reports published in 2019. Inaddition, we introduce the promising results in clinical trials of new–targetedimmunotherapies for these diseases.