神経治療学
Online ISSN : 2189-7824
Print ISSN : 0916-8443
ISSN-L : 2189-7824
シンポジウム18:神経変性疾患の画像診断トピックス
日常診療機器を用いたParkinson病関連疾患の診断と病態解明
伊藤 瑞規植田 晃広島 さゆり水谷 泰彰長尾 龍之介前田 利樹坂野 文彦渡辺 宏久
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2022 年 39 巻 4 号 p. 608-611

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Now, the various images are necessary for the differential diagnosis of neurodegenerative diseases, and brain MRI and brain perfusion SPECT are widely used in daily medical practices. Furthermore, in the diagnosis of Parkinson related disorders, the images such as myocardial MIBG scintigraphy and dopamine transporter scintigraphy are useful, but not sufficient. Therefore, we assess that it is possible to obtain useful information for the differential diagnoses and elucidation of neurodegenerative diseases by introducing the new settings and the image analysis methods in common medical devices. 1) We developed Individual Voxel–based Morphometry Adjusting Covariates (iVAC), a new voxel–based morphometry for brain MRI. By evaluating the atrophy of the putamen, pons, and middle cerebellar peduncle, we could show the possibility of distinguishing between multiple system atrophy and Parkinson disease with high accuracy. 2) By evaluating the atrophy of the nucleus ruber and the subthalamic nucleus using quantitative susceptibility mapping, we are trying to distinguish Parkinson disease from progressive supranuclear palsy. 3) By analyzing the brain perfusion SPECT in many Parkinson disease cases, we are trying to show that the blood flow decrease of the occipital lobe is the remote effect. 4) We succeeded in developing the serotonin transporter imaging by utilizing the property that 123I–ioflupane, which is the nuclide of the dopamine transporter scintigraphy, also binds to serotonin transporter. We are trying to evaluate the abnormality of the serotonin transporter in multiple system atrophy, in which medullary serotonin nerve loss was reported.

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