シンポジウム20：新規抗てんかん薬の使い方―update 2021
合理的併用療法を実践するために有用な抗てんかん薬の薬力学特性 ―てんかん治療における行動障害へのアプローチ―
2022 年 39 巻 4 号 p. 641-645
詳細
2022 年 39 巻 4 号 p. 641-645
Psychiatric disorders comorbid with patients with epilepsy are classified into antiseizure drug induced behavioural adverse reaction, ictal–related and interictal psychiatric disorders. Topiramate, levetiracetam and perampanel have been considered to be high risk antiseizure drugs for antiseizure drug induced behavioural adverse effect (BAE). Neither the diagnosis and treatment for the BAE remained to be clarified. Currently, switching of the causative antiseizure drug is recommended for treatment of BAE. Recently, the pathophysiology of BAE is exploring, and then several hypotheses suggested the similarities of pathomechanisms among ADHD, autism spectrum disorders and BAE.
