シンポジウム20：てんかんの病態と治療Update
てんかんの病態治療解明の融合的新知見へのアプローチ ～アストロサイトと細胞外Kホメオスタシスの破綻，伝播機構の仮説～
2023 年 40 巻 4 号 p. 611-616
詳細
2023 年 40 巻 4 号 p. 611-616
The cardinal findings of basic and clinical physiology of epileptic seizures have been regarded as “paroxysmal depolarization shifts” (PDS) at the postsynaptic membrane and it correspond to epileptiform discharge in EEG.
In addition, a recent new finding is that the impairment of extracellular K homeostasis in the synaptic cleft. It is mediated by astrocyte dysfunction at tripartite synapses. Namely, decreased expression of Kir 4.1 channel activity in the astrocytes is one of the most responsible factors in both animal and human epilepsy. It is also directly involved in the generator mechanism of ictal DC shifts (Ikeda et al, 1996), and would play a significant role in the propagation mechanisms of focal seizures.
