Abstract
The authors conducted a clinical analysis of 34 patients with odontogenic infections who required inpatient treatment in our department during the approximately 3.5-year period between April 2014 and September 2017. The patients ranged in age from 15 to 92 years. In the largest number of cases, the infection was caused by molar teeth, and in many cases, the contagion channel for the inflammation was found to be the submandibular gap. In the largest number of cases （21 patients）, the first antimicrobial agent used was ampicillin/sulbactam （ABPC/SBT）. Twenty-two patients received conservative management with antimicrobial medication alone, while 12 patients underwent anti-inflammatory surgery. The mean duration of hospitalization was 8.4 days. In severe cases of odontogenic infection, drug doses and administration intervals must be in line with theories relating to the pharmacokinetics and pharmacodynamics of antimicrobial agents （PK/PD theory）, and antimicrobial agents that take the primary causative organism into consideration need to be administered promptly. Even when the appropriate antimicrobial agent is administered with the patient hospitalized, immobilized, and under nutritional management, the authors also believe that it is important to administer these agents transvenously.
