Histological Changes around the Apatite 2-Piece Implants with Guided Tissue Regeneration Technique

Abstract

Clinical application of bone augmentation using the guided tissue regeneration (GTR) technique has been discussed for the last decade. In this study, we investigated new bone formation around apatite implants using a membrane technique. Apatite 2-piece implants were inserted in the tibiae of rabbits and then covered with a non-resorbable membrane (Sellulose membrane) or resorbable membrane (Collagen membrane). Animals were sacrificed after two, four, and eight weeks. The specimens containing the implants and peripheral tissue were prepared for histological examination. Under light microscopic observation, significant new bone formations were seen in membrane groups as compared with non-membrane group.