Experimental Study of Bone Formations by BMP-HAP Composite in Dog Mandibular Bone Cavity

Abstract

Hydroxyapatite (HAP) is considered one of the best bioactive ceramics because of high bone conduction/induction in osteogenic tissue. Although it has several characteristics of an ideal bone substitute, it does not have bone induction in heterogenous tissue. On the other hand, partially purified bone morphogenetic protein (BMP), which contains BMP-2 and can induce differentiation of mesenchymal cells into bone, was extracted from bovine bone matrix. In this study, dense HAP-BMP (Heparin-BMP) composites produced new bone faster than dense HAP alone after inserted into the bone cavity of the dog mandible. From the results of this study, HAP-BMP composite was found to have excellent bone induction in osteogenic tissue of the dog.