Histological Study of Bone Formation by Partialy Purified BMP in Dog Mandibular Bone Cavity

Abstract

The purpose of this study was to promote bone formation in the bone cavity after insertion of two kinds of partially perified bone morphogenetic protein (BMP). After insertion in the dog mandible, materials evaluated by histological study at 1, 3, and 5 weeks. G-Ext level BMP (G-Ext BMP) alone and Heparin level BMP-Insoluble bone matrixcomposites (SMP-IBM) produced new bone rapidly. G-Ext BMP and Heparin BMP quickly induced differentiation of the mesenchymal cells into osteoblastic cells in bone cavity of the dog mandible.