Two cases of mandibular squamous cell carcinoma as the second malignancy of malignant lymphoma

Abstract

As society ages and inspection technology develops, the incidence of secondary malignancies has increased. Esophageal and gastric cancers are common for primary tumors of oral secondary malignancies, but, on the otherhand, ML (malignant lymphomas) are rare. We report here two cases of mandibular SCC (squamous cell carcinoma) complicated with ML as metachronous secondary malignancies. In both cases, oral SCCs were aggressive and the clinical courses were rapid.
Case 1 was a 62-year-old man who had a past history of CLL (chronic lymphocytic leukemia)/SLL (small lymphocytic lymphoma) and developed oral SCC.
Though he had a surgical resection after chemoradiotherapy, SCC recurred just two months post operation.
Case 2 was an 83-year-old man who developed oral SCC during treatment for Epstein-Barr Virus (EBV)-positive DLBCL (diffuse large B-celllymphoma) of the elderly. He discontinued chemotherapy and he had an operation for oral SCC. Etoposide was resumed for exacerbation of EBV-positive DLBCL of the elderly; he is alive without any relapse of oral SCC.
Aggressive clinical features of secondary oral malignancies are considered to be closely related to a long-term immunosuppressive state due to ML and chemotherapy.