口腔・中咽頭がん患者の放射線性顎骨壊死発症リスク因子について：多施設共同後ろ向き研究の結果より

兒島 由佳; 河岡 有美; 川下 由美子; 山田 慎一; 栗田 浩; 長谷川 巧実; 古森 孝英; 明石 昌也; 上田 順宏; 桐田 忠昭; 高島 裕之; 渋谷 恭之; 梅田 正博

doi:10.5843/jsot.31.117

Symposium 2: What is perioperative oral management in oral cancer treatment?

Risk factors for osteoradionecrosis in patients with oral or oropharyngeal cancer : Results of a multicenter retrospective study

Yuka Kojima, Yumi Kawaoka, Yumiko Kawashita, Shin-ichi Yamada, Hiroshi Kurita, Takumi Hasegawa, Takahide Komori, Masaya Akashi, Nobuhiro Ueda, Tadaaki Kirita, Hiroyuki Takashima, Yasuyuki Shibuya, Masahiro Umeda

Author information

Yuka Kojima
Department of Dentistry and Oral Surgery, Kansai Medical University
Yumi Kawaoka
Department of Dentistry and Oral Surgery, Kansai Medical University
Yumiko Kawashita
Oral Management Center, Nagasaki University Hospital
Shin-ichi Yamada
Department of Dentistry and Oral Surgery, Shinshu University School of Medicine
Hiroshi Kurita
Department of Dentistry and Oral Surgery, Shinshu University School of Medicine
Takumi Hasegawa
Department Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine
Takahide Komori
Department Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine
Masaya Akashi
Department Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine
Nobuhiro Ueda
Department of Oral and Maxillofacial Surgery, Nara Medical University
Tadaaki Kirita
Department of Oral and Maxillofacial Surgery, Nara Medical University
Hiroyuki Takashima
Department of Oral and Maxillofacial Surgery, Nagoya City University Graduate School of Medical Sciences
Yasuyuki Shibuya
Department of Oral and Maxillofacial Surgery, Nagoya City University Graduate School of Medical Sciences
Masahiro Umeda
Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences

Keywords: osteoradionecrosis of the jaw, oral cancer, oropharyngeal cancer, risk factor, multicenter study

JOURNAL FREE ACCESS

2019 Volume 31 Issue 3 Pages 117-120

DOI https://doi.org/10.5843/jsot.31.117

Details

Abstract

Risk factors for development of osteoradionecrosis （ORN） of the jaw in patients with oral or oropharyngeal cancer who underwent radiotherapy between 2008 and 2017 at six hospitals were analyzed by Cox’s proportional hazard model. Periapical lesion, severer periodontal disease, and higher serum creatinine level significantly increased the risk of ORN, whereas IMRT and tooth extraction before RT significantly decreased the risk. Tooth extraction after RT seemed to increase the risk of ORN, though not significantly. It is necessary to establish a method for preventing ORN in future.

Corresponding author

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